TissueLink Topical Skin Adhesive – FAQ

tissueLINK™ topical skin adhesive is the proven choice for wound closure with over 40 years of clinical experience and more than 1000 articles iand clinical publications worldwide. Manufactured by B. Braun, tissueLINK™ consists of n-Butyl-2 Cyanoacrylate and is available in two formulations, clear & blue. The following document contains Frequently Asked Questions (FAQs) about tissueLINK™ skin adhesive and the unique features of this tissue adhesive.

Topical Skin Adhesive
Topical Skin Adhesive in clear, blue and flexible
  • tissueLink™ requires only one layer of adhesive versus two to three layers required for Dermabond®
  • tissueLINK™ achieves twice the tensile strength of Dermabond®.
  • tissueLINK™ sets up in under a minute versus 60-90 seconds per layer for Dermabond®.
  • tissueLINK™ is the only tissue adhesive available in the clear formulation.
  • tissueLINK™ is dispensed via a precise, non-clogging delivery system requiring no direct contact with the wound.
  • tissueLINK™ polymerizes in contact with moisture and allows 95%+ of the ampoule to be used.
  • tissueLINK™ provides 19% greater tensile strength than Indermil®.
  • tissueLINK™ is this only tissue adhesive available in the clear formulation.
  • tissueLINK™ is dispensed via a complete delivery system that requires no additional tip to adjust between
    a fine point tip or wide opening – just cut the tip to the desired width and flow rate.
  • tissueLINK™ leaves a clean, smooth appearance once polymerized while Indermil® generally appears
    yellow and often leaves a crystal residue due to the additives required to stabilize the product.
  • tissueLINK™ is 98% pure n-Butyl cyanoacrylates where Indermil® contains plasticizers, stabilizers, and
    formaldehyde.

No, tissueLINK™ does not leave a crystal residue. Indermil® often leaves a crystal residue because of the plasticizers and the amount of formaldehyde in the adhesive. The formaldehyde causes the adhesive to crystallize after it has polymerized on the skin. This makes the adhesive susceptible to breaking and flaking off of the skin.

tissueLINK™ can be used in any place sutures are used except in areas of high tension. tissueLINK’s™ indication for use is the same as Dermabond® and Indermil®. tissueLINK™ can be used in areas where precise application in required such as around the eye and in the hair – these are areas where use of Dermabond® and/or Indermil® is contraindicated.

tissueLINK™ in the clear formulation is made possible due to the cold micro-filter sterilization process. This sterilization process allows our composition to be over 99% pure without degrading the performance characteristics of the product. The clear formulation may be better in procedures where a good cosmetic outcome is desired. Blue is more appropriate for trauma cases to guage where & how much adhesive has been applied.

tissueLINK™ is one of only four Class III topical skin adhesives approved by the FDA for use of the United States. While there are a number of other tissue adhesives being marketed in the United States, they are being used without FDA clearance.

Yes you can. Avoid contact with water for the first 24 hours after treatment and minimize contact with water for an additional 7-10 days. For example, patients may shower or bathe but allow only transient wetting of the treatment site. The site should not be scrubbed, soaked or exposed to prolonged wetness for 7-10 days.

*Indermil® is an older generation product still in limited use in the field

The OEM trademarks identified herein are the trademarks of the respective OEMs, and not of Nissha Medical Technologies. Nissha Medical

Technologies disclaims any affiliation, connection, or association between its products and those of the respective OEMs.

TissueLINK Flex

butyl-cyanoacrylate with plasticizers

TissueLink Flex is preferred for use in areas of tension or that flex. Added plasticizers allow it to flex or bend without cracking the area.

ADVANTAGES

Flexibility:
The extra plasticizers allow closures of incisions up to 25cm

Microbial Barrier:
Studies shown to help prevent microorganizms that cause surgical site infection

Accuracy:
Special applicator tip permits better control and better application

More Comfort:
Generates less heat during polymerization

TissueLINK clear

Monomeric butyl-2-cyanoacrylate.

PREFERRED BY COSMETIC OR PLASTIC SURGEONS

  • Closes wound in under 1 minute!
  • Creates an Anti-Bacterial barrier to protect wounds.
  • Easy to use – 1 layer of adhesive provides optimal bonding strength
TissueLINK Blue

Monomeric butyl-2-cyanoacrylate.

MOST POPULAR TISSUE ADHESIVE

  • Closes wound in under 1 minute!
  • Creates an Anti-Bacterial barrier to protect wounds.
  • Easy to use – 1 layer of adhesive provides optimal bonding strength